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Enhancement of dissolution of Lercanidipine Hydrochloride using Solid Dispersion Technique

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Author Affiliations

  • 1Babaria Institute of Pharmacy, INDIA

Res. J. Recent Sci., Volume 4, Issue (ISC-2014), Pages 299-307, (2015)

Abstract

Lercanidipine hydrochloride (LER) is a BCS class II antihypertensive drug which results in limited oral bioavailability of 10%. The purpose of this study is to improve the dissolution and thus the bioavailability of LER by dispersing it into a hydrophilic polymer. Study involved incorporation of LER in a polymeric matrix of Polyethylene Glycol-6000 at a molecular level. Solid dispersions of LER were prepared by solvent evaporation and melt fusion techniques by varying drug to polymer ratio. The studies demonstrated that LER solid dispersions show increased solubility and dissolution rate in comparison with physical mixture and pure drug. Solid dispersion obtained by solvent evaporation and fusion techniques showed improved release i.e. 93.7% and 57% respectively as compared to pure LER and physical mixture 37.2% and 38.9% respectively in 1 hour. No interaction of LER and polymer was confirmed by DSC and IR studies. It can be confirmed from the obtained results that solid dispersion can be a method of choice for increasing the solubility, dissolution and in turn the bioavailability of Lercanidipine hydrochloride. It is also observed that out of two techniques employed for preparing solid dispersion, solvent evaporation technique shows challenging results.

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